A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä

Insight into human photoreceptor function: Modeling optoretinographic responses to diverse stimuli




TekijätValente, Denise; Vienola, Kari V.; Zawadzki, Robert J.; Jonnal, Ravi S.

KustantajaAmerican Association for the Advancement of Science (AAAS)

Julkaisuvuosi2025

JournalScience Advances

Tietokannassa oleva lehden nimiScience Advances

Artikkelin numeroeadq7332

Vuosikerta11

Numero24

eISSN2375-2548

DOIhttps://doi.org/10.1126/sciadv.adq7332

Verkko-osoitehttps://doi.org/10.1126/sciadv.adq7332

Rinnakkaistallenteen osoitehttps://research.utu.fi/converis/portal/detail/Publication/498420211


Tiivistelmä

Optoretinography is an emerging method for detecting and measuring functional responses from neurons in the living human retina. Its potential applications are compelling and broad, spanning clinical assessment of retinal disease, investigation of fundamental scientific questions, and rapid evaluation of experimental therapeutics for blinding retinal diseases. Progress in all these domains hinges on the development of robust methods for quantifying observed responses in relation to visible stimuli. In this work, we describe an optoretinographic imaging platform: full-field swept-source optical coherence tomography with adaptive optics, measure cone responses in two healthy volunteers to a variety of stimulus patterns, and propose a simple model for predicting and quantifying responses to those stimuli.


Ladattava julkaisu

This is an electronic reprint of the original article.
This reprint may differ from the original in pagination and typographic detail. Please cite the original version.




Julkaisussa olevat rahoitustiedot
Research Council of Finland (356826)


Last updated on 2025-16-06 at 13:20