A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Insight into human photoreceptor function: Modeling optoretinographic responses to diverse stimuli
Tekijät: Valente, Denise; Vienola, Kari V.; Zawadzki, Robert J.; Jonnal, Ravi S.
Kustantaja: American Association for the Advancement of Science (AAAS)
Julkaisuvuosi: 2025
Journal: Science Advances
Tietokannassa oleva lehden nimi: Science Advances
Artikkelin numero: eadq7332
Vuosikerta: 11
Numero: 24
eISSN: 2375-2548
DOI: https://doi.org/10.1126/sciadv.adq7332
Verkko-osoite: https://doi.org/10.1126/sciadv.adq7332
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/498420211
Optoretinography is an emerging method for detecting and measuring functional responses from neurons in the living human retina. Its potential applications are compelling and broad, spanning clinical assessment of retinal disease, investigation of fundamental scientific questions, and rapid evaluation of experimental therapeutics for blinding retinal diseases. Progress in all these domains hinges on the development of robust methods for quantifying observed responses in relation to visible stimuli. In this work, we describe an optoretinographic imaging platform: full-field swept-source optical coherence tomography with adaptive optics, measure cone responses in two healthy volunteers to a variety of stimulus patterns, and propose a simple model for predicting and quantifying responses to those stimuli.
Ladattava julkaisu This is an electronic reprint of the original article. |
Julkaisussa olevat rahoitustiedot:
Research Council of Finland (356826)