A1 Refereed original research article in a scientific journal
Insight into human photoreceptor function: Modeling optoretinographic responses to diverse stimuli
Authors: Valente, Denise; Vienola, Kari V.; Zawadzki, Robert J.; Jonnal, Ravi S.
Publisher: American Association for the Advancement of Science (AAAS)
Publication year: 2025
Journal: Science Advances
Journal name in source: Science Advances
Article number: eadq7332
Volume: 11
Issue: 24
eISSN: 2375-2548
DOI: https://doi.org/10.1126/sciadv.adq7332
Web address : https://doi.org/10.1126/sciadv.adq7332
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/498420211
Optoretinography is an emerging method for detecting and measuring functional responses from neurons in the living human retina. Its potential applications are compelling and broad, spanning clinical assessment of retinal disease, investigation of fundamental scientific questions, and rapid evaluation of experimental therapeutics for blinding retinal diseases. Progress in all these domains hinges on the development of robust methods for quantifying observed responses in relation to visible stimuli. In this work, we describe an optoretinographic imaging platform: full-field swept-source optical coherence tomography with adaptive optics, measure cone responses in two healthy volunteers to a variety of stimulus patterns, and propose a simple model for predicting and quantifying responses to those stimuli.
Downloadable publication This is an electronic reprint of the original article. |
Funding information in the publication:
Research Council of Finland (356826)