A1 Refereed original research article in a scientific journal

Insight into human photoreceptor function: Modeling optoretinographic responses to diverse stimuli




AuthorsValente, Denise; Vienola, Kari V.; Zawadzki, Robert J.; Jonnal, Ravi S.

PublisherAmerican Association for the Advancement of Science (AAAS)

Publication year2025

JournalScience Advances

Journal name in sourceScience Advances

Article numbereadq7332

Volume11

Issue24

eISSN2375-2548

DOIhttps://doi.org/10.1126/sciadv.adq7332

Web address https://doi.org/10.1126/sciadv.adq7332

Self-archived copy’s web addresshttps://research.utu.fi/converis/portal/detail/Publication/498420211


Abstract

Optoretinography is an emerging method for detecting and measuring functional responses from neurons in the living human retina. Its potential applications are compelling and broad, spanning clinical assessment of retinal disease, investigation of fundamental scientific questions, and rapid evaluation of experimental therapeutics for blinding retinal diseases. Progress in all these domains hinges on the development of robust methods for quantifying observed responses in relation to visible stimuli. In this work, we describe an optoretinographic imaging platform: full-field swept-source optical coherence tomography with adaptive optics, measure cone responses in two healthy volunteers to a variety of stimulus patterns, and propose a simple model for predicting and quantifying responses to those stimuli.


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Funding information in the publication
Research Council of Finland (356826)


Last updated on 2025-16-06 at 13:20