A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Low‐grade systemic inflammation biomarkers in sedentary young healthy adults are not significantly affected by a 24‐week concurrent training intervention
Tekijät: Vázquez-Lorente, Héctor; Herrera-Quintana, Lourdes; Acosta, Francisco M.; Amaro-Gahete, Francisco J.; Ruiz, Jonatan R.
Kustantaja: John Wiley & Sons
Kustannuspaikka: HOBOKEN
Julkaisuvuosi: 2025
Journal: Annals of the New York Academy of Sciences
Tietokannassa oleva lehden nimi: Annals of the New York Academy of Sciences
Lehden akronyymi: ANN NY ACAD SCI
Sivujen määrä: 16
ISSN: 0077-8923
eISSN: 1749-6632
DOI: https://doi.org/10.1111/nyas.15329
Verkko-osoite: https://doi.org/10.1111/nyas.15329
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/491847938
In this study, we measured the dose-response effect of a 24-week concurrent training (CT) intervention on low-grade systemic inflammation biomarkers in sedentary young healthy adults. A total of 100 untrained participants were randomized to (1) no exercise (control group, n = 35), (2) aerobic + resistance exercise (CT) at moderate intensity (exercise-moderate group; n = 33), or (3) CT at vigorous intensity (exercise-vigorous group, n = 32). Serum concentrations of C-reactive protein (CRP), interleukin-6 (IL-6), IL-7, IL-8, and IL-10, interferon-gamma (IFN-γ), tumor necrosis factor-α, leptin, and adiponectin were determined and compared among the three groups. The exercise-vigorous group members had lower differences in IL-7 levels among them, compared to the exercise-moderate group members (Δ = -7.97% vs. 1.90%; p = 0.030; 95% CI [-0.90, -0.04]). The exercise-vigorous group members showed higher differences in CRP values (Δ = 20.1%; F = 3.339; p = 0.046) compared to both the control (Δ = -1.91%) and the exercise-moderate (Δ = -23.3%) group members, whereas the control group exhibited higher differences in IFN-γ levels compared to the exercise-vigorous group (Δ = 15.3% vs. 2.62%; p = 0.048; 95% CI [-0.68, -0.01]). For individuals in the three groups, body composition and physical fitness correlated overall with leptin. The data show, and we concluded, that the training intervention had no significant effect on low-grade systemic inflammation biomarkers.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
Julkaisussa olevat rahoitustiedot:
Spanish Ministry of Economy and Competitiveness via the Fondo de Investigación Sanitaria del Instituto de Salud Carlos III.
Grant Numbers: PI13/01393, PTA-12264
Retos de la Sociedad.
Grant Number: DEP2016-79512-R
Spain and European Regional Development Funds
Fundación Iberoamericana de Nutrición
Redes Temáticas de Investigación Cooperativa RETIC.
Grant Number: RD16/0022
Spain; the AstraZeneca HealthCare Foundation
The University of Granada Plan Propio de Investigación 2016 – Excellence actions:
Unit of Excellence on Exercise Nutrition and Health
Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades,
The Fundación Alfonso Martin Escudero
Marie Sklodowska-Curie fellowship.
Grant Numbers: 101065356, MSCA 2021
Research Council of Finland.
Grant Number: 348017
Research Council of Finland's Flagship InFLAMES.
Grant Numbers: 337530, 357910
EXERNET Research Network on Exercise and Health.
Grant Numbers: DEP2005-00046/ACTI, 09/UPB/19, 45/UPB/20, 27/UPB/21
