Low‐grade systemic inflammation biomarkers in sedentary young healthy adults are not significantly affected by a 24‐week concurrent training intervention - UTU Research Portal

A1 Refereed original research article in a scientific journal

Low‐grade systemic inflammation biomarkers in sedentary young healthy adults are not significantly affected by a 24‐week concurrent training intervention

Authors: Vázquez-Lorente, Héctor; Herrera-Quintana, Lourdes; Acosta, Francisco M.; Amaro-Gahete, Francisco J.; Ruiz, Jonatan R.

Publisher: John Wiley & Sons

Publishing place: HOBOKEN

Publication year: 2025

Journal: Annals of the New York Academy of Sciences

Journal name in source: Annals of the New York Academy of Sciences

Journal acronym: ANN NY ACAD SCI

Number of pages: 16

ISSN: 0077-8923

eISSN: 1749-6632

DOI: https://doi.org/10.1111/nyas.15329

Web address : https://doi.org/10.1111/nyas.15329

Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/491847938

Abstract

In this study, we measured the dose-response effect of a 24-week concurrent training (CT) intervention on low-grade systemic inflammation biomarkers in sedentary young healthy adults. A total of 100 untrained participants were randomized to (1) no exercise (control group, n = 35), (2) aerobic + resistance exercise (CT) at moderate intensity (exercise-moderate group; n = 33), or (3) CT at vigorous intensity (exercise-vigorous group, n = 32). Serum concentrations of C-reactive protein (CRP), interleukin-6 (IL-6), IL-7, IL-8, and IL-10, interferon-gamma (IFN-γ), tumor necrosis factor-α, leptin, and adiponectin were determined and compared among the three groups. The exercise-vigorous group members had lower differences in IL-7 levels among them, compared to the exercise-moderate group members (Δ = -7.97% vs. 1.90%; p = 0.030; 95% CI [-0.90, -0.04]). The exercise-vigorous group members showed higher differences in CRP values (Δ = 20.1%; F = 3.339; p = 0.046) compared to both the control (Δ = -1.91%) and the exercise-moderate (Δ = -23.3%) group members, whereas the control group exhibited higher differences in IFN-γ levels compared to the exercise-vigorous group (Δ = 15.3% vs. 2.62%; p = 0.048; 95% CI [-0.68, -0.01]). For individuals in the three groups, body composition and physical fitness correlated overall with leptin. The data show, and we concluded, that the training intervention had no significant effect on low-grade systemic inflammation biomarkers.

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Funding information in the publication:
Spanish Ministry of Economy and Competitiveness via the Fondo de Investigación Sanitaria del Instituto de Salud Carlos III.
Grant Numbers: PI13/01393, PTA-12264

Retos de la Sociedad.
Grant Number: DEP2016-79512-R

Spain and European Regional Development Funds

Fundación Iberoamericana de Nutrición

Redes Temáticas de Investigación Cooperativa RETIC.
Grant Number: RD16/0022

Spain; the AstraZeneca HealthCare Foundation

The University of Granada Plan Propio de Investigación 2016 – Excellence actions:
Unit of Excellence on Exercise Nutrition and Health

Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades,
The Fundación Alfonso Martin Escudero

Marie Sklodowska-Curie fellowship.
Grant Numbers: 101065356, MSCA 2021

Research Council of Finland.
Grant Number: 348017

Research Council of Finland's Flagship InFLAMES.
Grant Numbers: 337530, 357910

EXERNET Research Network on Exercise and Health.
Grant Numbers: DEP2005-00046/ACTI, 09/UPB/19, 45/UPB/20, 27/UPB/21