A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Preeclampsia does not share common risk alleles in 9p21 with coronary artery disease and type 2 diabetes
Tekijät: Kaartokallio, Tea; Lokki, Inkeri A; Peterson, Hanna; Kivinen, Katja Hiltunen, Leena; Salmela, Elina; Lappalainen, Tuuli; Maanselkä, Paula; Heino, Sanna; Knuutila. Sari; Sayed, Ayat; Poston, Lucilla; Brennecke, Shaun P.; Johnson, Matthew P.; Morgan, Linda; Moses, Eric K.; Kere, Juha; Laivuori, Hannele
Kustantaja: Taylor & Francis
Julkaisuvuosi: 2016
Lehti:Annals of Medicine
Tietokannassa oleva lehden nimiAnnals of Medicine
Vuosikerta: 48
Numero: 5
ISSN: 0785-3890
DOI: https://doi.org/10.1080/07853890.2016.1174877
Verkko-osoite: https://www.tandfonline.com/doi/full/10.1080/07853890.2016.1174877
Introduction: Preeclampsia is a common and partially genetic pregnancy complication characterized by hypertension and proteinuria. Association with cardiovascular disease and type 2 diabetes has been reported in 9p21 by several genome-wide association studies. It has been hypothesized that cardiometabolic diseases may share common etiology with preeclampsia.Materials and methods: We tested association with the 9p21 region to preeclampsia in the Finnish population by genotyping 23 tagging single nucleotide polymorphisms (SNPs) in 15 extended preeclampsia families and in a nationwide cohort consisting of 281 cases and 349 matched controls. Replication was conducted in additional datasets.Results: Four SNPs (rs7044859, rs496892, rs564398 and rs7865618) showed nominal association (pConclusions: Our study did not find evidence for the involvement of the 9p21 region in the risk of preeclampsia.
