Preeclampsia does not share common risk alleles in 9p21 with coronary artery disease and type 2 diabetes - UTU Research Portal

A1 Refereed original research article in a scientific journal

Preeclampsia does not share common risk alleles in 9p21 with coronary artery disease and type 2 diabetes

Authors: Kaartokallio, Tea; Lokki, Inkeri A; Peterson, Hanna; Kivinen, Katja Hiltunen, Leena; Salmela, Elina; Lappalainen, Tuuli; Maanselkä, Paula; Heino, Sanna; Knuutila. Sari; Sayed, Ayat; Poston, Lucilla; Brennecke, Shaun P.; Johnson, Matthew P.; Morgan, Linda; Moses, Eric K.; Kere, Juha; Laivuori, Hannele

Publisher: Taylor & Francis

Publication year: 2016

Journal:Annals of Medicine

Journal name in sourceAnnals of Medicine

Volume: 48

Issue: 5

ISSN: 0785-3890

DOI: https://doi.org/10.1080/07853890.2016.1174877

Web address : https://www.tandfonline.com/doi/full/10.1080/07853890.2016.1174877

Abstract

Introduction: Preeclampsia is a common and partially genetic pregnancy complication characterized by hypertension and proteinuria. Association with cardiovascular disease and type 2 diabetes has been reported in 9p21 by several genome-wide association studies. It has been hypothesized that cardiometabolic diseases may share common etiology with preeclampsia.Materials and methods: We tested association with the 9p21 region to preeclampsia in the Finnish population by genotyping 23 tagging single nucleotide polymorphisms (SNPs) in 15 extended preeclampsia families and in a nationwide cohort consisting of 281 cases and 349 matched controls. Replication was conducted in additional datasets.Results: Four SNPs (rs7044859, rs496892, rs564398 and rs7865618) showed nominal association (pConclusions: Our study did not find evidence for the involvement of the 9p21 region in the risk of preeclampsia.