A1 Refereed original research article in a scientific journal

Organomercury oligonucleotide-polydopamine nanoparticle assemblies discriminate between target sequences by Hg(ii)-mediated base pairing



Authors: Kotammagari, Tharun K.; Al-Waeel, Majid; Lukkari, Jukka; Lönnberg, Tuomas

Publisher: Royal Society of Chemistry

Publication year: 2024

Journal: RSC Advances

Journal name in source: RSC ADVANCES

Volume: 14

Issue: 51

First page : 38279

Last page: 38284

eISSN: 2046-2069

DOI: https://doi.org/10.1039/d4ra07922a

Web address : https://doi.org/10.1039/D4RA07922A

Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/477189139


Abstract

A fluorescently tagged oligonucleotide hybridization probe incorporating a single 5-mercuricytosine residue was synthesized and found to adsorb on polydopamine nanoparticles much more strongly than its unmetallated counterpart. Hybridization with target sequences led to release of the probe from the nanoparticle to varying degrees depending on the nucleobase opposite to 5-mercuricytosine.


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Last updated on 2025-27-01 at 19:14