Piecing Together a Broken Tumor Suppressor Phosphatase for Cancer Therapy

: Westermarck J, Neel BG

Publisher: CELL PRESS

: 2020

: Cell

: CELL

: 181

: 3

: 514

: 517

: 5

: 0092-8674

: 1097-4172

DOI: https://doi.org/10.1016/j.cell.2020.04.005

Members of the PP2A family of serine/threonine phosphatases are important human tumor suppressor genes. Unlikemost tumor suppressors, they are rarely mutated/deleted, but rather are impaired by "inhibitor proteins.'' Two papers in this issue of Cell show how some phenothiazine derivatives reactivate specific PP2A isozymes with potential benefit in cancer and other diseases.