B1 Non-refereed article in a scientific journal

Piecing Together a Broken Tumor Suppressor Phosphatase for Cancer Therapy



Authors: Westermarck J, Neel BG

Publisher: CELL PRESS

Publication year: 2020

Journal: Cell

Journal name in source: CELL

Journal acronym: CELL

Volume: 181

Issue: 3

First page : 514

Last page: 517

Number of pages: 5

ISSN: 0092-8674

eISSN: 1097-4172

DOI: https://doi.org/10.1016/j.cell.2020.04.005


Abstract
Members of the PP2A family of serine/threonine phosphatases are important human tumor suppressor genes. Unlikemost tumor suppressors, they are rarely mutated/deleted, but rather are impaired by "inhibitor proteins.'' Two papers in this issue of Cell show how some phenothiazine derivatives reactivate specific PP2A isozymes with potential benefit in cancer and other diseases.



Last updated on 2024-26-11 at 17:32