B1 Vertaisarvioimaton kirjoitus tieteellisessä lehdessä
Piecing Together a Broken Tumor Suppressor Phosphatase for Cancer Therapy
Tekijät: Westermarck J, Neel BG
Kustantaja: CELL PRESS
Julkaisuvuosi: 2020
Journal: Cell
Tietokannassa oleva lehden nimi: CELL
Lehden akronyymi: CELL
Vuosikerta: 181
Numero: 3
Aloitussivu: 514
Lopetussivu: 517
Sivujen määrä: 5
ISSN: 0092-8674
eISSN: 1097-4172
DOI: https://doi.org/10.1016/j.cell.2020.04.005
Tiivistelmä
Members of the PP2A family of serine/threonine phosphatases are important human tumor suppressor genes. Unlikemost tumor suppressors, they are rarely mutated/deleted, but rather are impaired by "inhibitor proteins.'' Two papers in this issue of Cell show how some phenothiazine derivatives reactivate specific PP2A isozymes with potential benefit in cancer and other diseases.
Members of the PP2A family of serine/threonine phosphatases are important human tumor suppressor genes. Unlikemost tumor suppressors, they are rarely mutated/deleted, but rather are impaired by "inhibitor proteins.'' Two papers in this issue of Cell show how some phenothiazine derivatives reactivate specific PP2A isozymes with potential benefit in cancer and other diseases.
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