A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Metal-Mediated Base Pairing of Rigid and Flexible Benzaldoxime Metallacycles
Tekijät: Maity S, Hande M, Lönnberg T
Kustantaja: WILEY-V C H VERLAG GMBH
Julkaisuvuosi: 2020
Journal: ChemBioChem
Tietokannassa oleva lehden nimi: CHEMBIOCHEM
Lehden akronyymi: CHEMBIOCHEM
Vuosikerta: 21
Numero: 16
Sivujen määrä: 9
ISSN: 1439-4227
eISSN: 1439-7633
DOI: https://doi.org/10.1002/cbic.202000135
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/47222924
Tiivistelmä
Oligonucleotides incorporating a central C-nucleoside with either a rigid or flexible benzaldoxime base moiety have been synthesized, and the hybridization properties of their metallacyclic derivatives have been studied by UV melting experiments. In all cases, the metallated duplexes were less stable than their unmetallated counterparts, and the metallacyclic nucleobases did not show a clear preference for any of the canonical nucleobases as a base-pairing partner. With palladated oligonucleotides, increased flexibility translated to less severe destabilization, whereas the opposite was true for the mercurated oligonucleotides; this reflects the greater difficulties in accommodating a rigid Pd-II-mediated base pair than a rigid Hg-II-mediated base pair within the base stack of a double helix.
Oligonucleotides incorporating a central C-nucleoside with either a rigid or flexible benzaldoxime base moiety have been synthesized, and the hybridization properties of their metallacyclic derivatives have been studied by UV melting experiments. In all cases, the metallated duplexes were less stable than their unmetallated counterparts, and the metallacyclic nucleobases did not show a clear preference for any of the canonical nucleobases as a base-pairing partner. With palladated oligonucleotides, increased flexibility translated to less severe destabilization, whereas the opposite was true for the mercurated oligonucleotides; this reflects the greater difficulties in accommodating a rigid Pd-II-mediated base pair than a rigid Hg-II-mediated base pair within the base stack of a double helix.
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