A1 Refereed original research article in a scientific journal
Metal-Mediated Base Pairing of Rigid and Flexible Benzaldoxime Metallacycles
Authors: Maity S, Hande M, Lönnberg T
Publisher: WILEY-V C H VERLAG GMBH
Publication year: 2020
Journal: ChemBioChem
Journal name in source: CHEMBIOCHEM
Journal acronym: CHEMBIOCHEM
Volume: 21
Issue: 16
Number of pages: 9
ISSN: 1439-4227
eISSN: 1439-7633
DOI: https://doi.org/10.1002/cbic.202000135
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/47222924
Abstract
Oligonucleotides incorporating a central C-nucleoside with either a rigid or flexible benzaldoxime base moiety have been synthesized, and the hybridization properties of their metallacyclic derivatives have been studied by UV melting experiments. In all cases, the metallated duplexes were less stable than their unmetallated counterparts, and the metallacyclic nucleobases did not show a clear preference for any of the canonical nucleobases as a base-pairing partner. With palladated oligonucleotides, increased flexibility translated to less severe destabilization, whereas the opposite was true for the mercurated oligonucleotides; this reflects the greater difficulties in accommodating a rigid Pd-II-mediated base pair than a rigid Hg-II-mediated base pair within the base stack of a double helix.
Oligonucleotides incorporating a central C-nucleoside with either a rigid or flexible benzaldoxime base moiety have been synthesized, and the hybridization properties of their metallacyclic derivatives have been studied by UV melting experiments. In all cases, the metallated duplexes were less stable than their unmetallated counterparts, and the metallacyclic nucleobases did not show a clear preference for any of the canonical nucleobases as a base-pairing partner. With palladated oligonucleotides, increased flexibility translated to less severe destabilization, whereas the opposite was true for the mercurated oligonucleotides; this reflects the greater difficulties in accommodating a rigid Pd-II-mediated base pair than a rigid Hg-II-mediated base pair within the base stack of a double helix.
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