A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä
Unravelling monocyte functions: from the guardians of health to the regulators of disease
Tekijät: Mildner, Alexander; Kim, Ki-Wook; Yona, Simon
Kustantaja: Oxford University Press
Julkaisuvuosi: 2024
Journal: Discovery Immunology
Artikkelin numero: kyae014
Vuosikerta: 3
Numero: 1
eISSN: 2754-2483
DOI: https://doi.org/10.1093/discim/kyae014
Verkko-osoite: https://doi.org/10.1093/discim/kyae014
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/458873530
Monocytes are a key component of the innate immune system. They undergo intricate developmental processes within the bone marrow, leading to diverse monocyte subsets in the circulation. In a state of healthy homeostasis, monocytes are continuously released into the bloodstream, destined to repopulate specific tissue-resident macrophage pools where they fulfil tissue-specific functions. However, under pathological conditions monocytes adopt various phenotypes to resolve inflammation and return to a healthy physiological state. This review explores the nuanced developmental pathways and functional roles that monocytes perform, shedding light on their significance in both physiological and pathological contexts.
Ladattava julkaisu This is an electronic reprint of the original article. |
Julkaisussa olevat rahoitustiedot:
A.M. is supported by the Research Council of Finland’s Flagship InFLAMES (337530 and 357910), the German Research Foundation (SPP2395; MI1328), the Jane and Aatos Erkko Foundation, the Sigrid Juselius Foundation, and the Research Council of Finland (355727). SY is supported by the Israel Science Foundation (192/20). K-W.K. is supported by National Institute of Health grant R01DK126753.