A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä

Unravelling monocyte functions: from the guardians of health to the regulators of disease




TekijätMildner, Alexander; Kim, Ki-Wook; Yona, Simon

KustantajaOxford University Press

Julkaisuvuosi2024

JournalDiscovery Immunology

Artikkelin numerokyae014

Vuosikerta3

Numero1

eISSN 2754-2483

DOIhttps://doi.org/10.1093/discim/kyae014

Verkko-osoitehttps://doi.org/10.1093/discim/kyae014

Rinnakkaistallenteen osoitehttps://research.utu.fi/converis/portal/detail/Publication/458873530


Tiivistelmä

Monocytes are a key component of the innate immune system. They undergo intricate developmental processes within the bone marrow, leading to diverse monocyte subsets in the circulation. In a state of healthy homeostasis, monocytes are continuously released into the bloodstream, destined to repopulate specific tissue-resident macrophage pools where they fulfil tissue-specific functions. However, under pathological conditions monocytes adopt various phenotypes to resolve inflammation and return to a healthy physiological state. This review explores the nuanced developmental pathways and functional roles that monocytes perform, shedding light on their significance in both physiological and pathological contexts.


Ladattava julkaisu

This is an electronic reprint of the original article.
This reprint may differ from the original in pagination and typographic detail. Please cite the original version.




Julkaisussa olevat rahoitustiedot
A.M. is supported by the Research Council of Finland’s Flagship InFLAMES (337530 and 357910), the German Research Foundation (SPP2395; MI1328), the Jane and Aatos Erkko Foundation, the Sigrid Juselius Foundation, and the Research Council of Finland (355727). SY is supported by the Israel Science Foundation (192/20). K-W.K. is supported by National Institute of Health grant R01DK126753.


Last updated on 2025-27-01 at 19:14