A2 Refereed review article in a scientific journal
Unravelling monocyte functions: from the guardians of health to the regulators of disease
Authors: Mildner, Alexander; Kim, Ki-Wook; Yona, Simon
Publisher: Oxford University Press
Publication year: 2024
Journal: Discovery Immunology
Article number: kyae014
Volume: 3
Issue: 1
eISSN: 2754-2483
DOI: https://doi.org/10.1093/discim/kyae014
Web address : https://doi.org/10.1093/discim/kyae014
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/458873530
Monocytes are a key component of the innate immune system. They undergo intricate developmental processes within the bone marrow, leading to diverse monocyte subsets in the circulation. In a state of healthy homeostasis, monocytes are continuously released into the bloodstream, destined to repopulate specific tissue-resident macrophage pools where they fulfil tissue-specific functions. However, under pathological conditions monocytes adopt various phenotypes to resolve inflammation and return to a healthy physiological state. This review explores the nuanced developmental pathways and functional roles that monocytes perform, shedding light on their significance in both physiological and pathological contexts.
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Funding information in the publication:
A.M. is supported by the Research Council of Finland’s Flagship InFLAMES (337530 and 357910), the German Research Foundation (SPP2395; MI1328), the Jane and Aatos Erkko Foundation, the Sigrid Juselius Foundation, and the Research Council of Finland (355727). SY is supported by the Israel Science Foundation (192/20). K-W.K. is supported by National Institute of Health grant R01DK126753.
