A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Heat stress sensitizes zebrafish embryos to neurological and cardiac toxicity
Tekijät: Haapanen-Saaristo, Anna-Mari; Virtanen, Noora; Tcarenkova, Elena; Vaparanta, Katri; Ampuja, Minna; Vehniainen, Eeva-Riikka; Paatero, Ilkka
Kustantaja: Elsevier BV
Kustannuspaikka: SAN DIEGO
Julkaisuvuosi: 2024
Journal: Biochemical and Biophysical Research Communications
Tietokannassa oleva lehden nimi: Biochemical and Biophysical Research Communications
Lehden akronyymi: BIOCHEM BIOPH RES CO
Artikkelin numero: 150682
Vuosikerta: 733
Sivujen määrä: 6
ISSN: 0006-291X
eISSN: 1090-2104
DOI: https://doi.org/10.1016/j.bbrc.2024.150682
Verkko-osoite: http://dx.doi.org/10.1016/j.bbrc.2024.150682
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/458320970
Global warming increases the risk of dangerous heat waves, which may have deleterious effects on humans and wildlife. Here, we have utilized zebrafish embryos as a model to analyze heat stress and effect of chemical compounds on responses to heat stress. The temperature adaptation limit of zebrafish embryos was 37 degree celsius in behavioural test and 38 degree celsius in cardiac test. Polyaromatic hydrocarbon phenanthrene completely blocked the behavioural adaptation to heat stress. Interestingly, the cardiotoxic effects of lapatinib, phenanthrene and paclitaxel were induced by heat stress. Taken together, our data indicates that motility and cardiac function of zebrafish embryos can be utilized as a model to analyze modulatory effects of compounds on heat stress.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
Julkaisussa olevat rahoitustiedot:
Finnish Foundation for Cardiovascular Research (IP, KV, MA), University of Turku Health, Diagnostics and Drug Development thematic collaboration funding (IP).
