A1 Refereed original research article in a scientific journal
Heat stress sensitizes zebrafish embryos to neurological and cardiac toxicity
Authors: Haapanen-Saaristo, Anna-Mari; Virtanen, Noora; Tcarenkova, Elena; Vaparanta, Katri; Ampuja, Minna; Vehniainen, Eeva-Riikka; Paatero, Ilkka
Publisher: Elsevier BV
Publishing place: SAN DIEGO
Publication year: 2024
Journal: Biochemical and Biophysical Research Communications
Journal name in source: Biochemical and Biophysical Research Communications
Journal acronym: BIOCHEM BIOPH RES CO
Article number: 150682
Volume: 733
Number of pages: 6
ISSN: 0006-291X
eISSN: 1090-2104
DOI: https://doi.org/10.1016/j.bbrc.2024.150682
Web address : http://dx.doi.org/10.1016/j.bbrc.2024.150682
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/458320970
Global warming increases the risk of dangerous heat waves, which may have deleterious effects on humans and wildlife. Here, we have utilized zebrafish embryos as a model to analyze heat stress and effect of chemical compounds on responses to heat stress. The temperature adaptation limit of zebrafish embryos was 37 degree celsius in behavioural test and 38 degree celsius in cardiac test. Polyaromatic hydrocarbon phenanthrene completely blocked the behavioural adaptation to heat stress. Interestingly, the cardiotoxic effects of lapatinib, phenanthrene and paclitaxel were induced by heat stress. Taken together, our data indicates that motility and cardiac function of zebrafish embryos can be utilized as a model to analyze modulatory effects of compounds on heat stress.
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Funding information in the publication:
Finnish Foundation for Cardiovascular Research (IP, KV, MA), University of Turku Health, Diagnostics and Drug Development thematic collaboration funding (IP).
