A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä
Systemic Factors Effecting Human Beta-Defensins in Oral Cavity
Tekijät: Atalay, Nur; Balci, Nur; Gürsoy, Mervi; Gürsoy, Ulvi Kahraman
Kustantaja: Multidisciplinary Digital Publishing Institute (MDPI)
Julkaisuvuosi: 2024
Journal: Pathogens
Tietokannassa oleva lehden nimi: Pathogens
Vuosikerta: 13
Numero: 8
eISSN: 2076-0817
DOI: https://doi.org/10.3390/pathogens13080654
Verkko-osoite: https://doi.org/10.3390/pathogens13080654
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/457762430
Human beta-defensins are host defense peptides with broad antimicrobial and inflammatory functions. In the oral cavity, these peptides are produced mainly by the keratinocytes of the epithelium; however, fibroblasts, monocytes, and macrophages also contribute to oral human beta-defensin expressions. The resident and immune cells of the oral cavity come into contact with various microbe-associated molecular patterns continuously and simultaneously. The overall antimicrobial cellular response is highly influenced by local and environmental factors. Recent studies have produced evidence showing that not only systemic chronic diseases but also systemic factors like hyperglycemia, pregnancy, the long-term use of certain vitamins, and aging can modulate oral cellular antimicrobial responses against microbial challenges. Therefore, the aim of this narrative review is to discuss the role of systemic factors on oral human beta-defensin expressions.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
Julkaisussa olevat rahoitustiedot:
This work was partly funded by the Finnish Dental Society Apollonia 2022-UKG, Minerva Foundation (Finland) 2023-UKG.
