A2 Refereed review article in a scientific journal

Systemic Factors Effecting Human Beta-Defensins in Oral Cavity




AuthorsAtalay, Nur; Balci, Nur; Gürsoy, Mervi; Gürsoy, Ulvi Kahraman

PublisherMultidisciplinary Digital Publishing Institute (MDPI)

Publication year2024

JournalPathogens

Journal name in sourcePathogens

Volume13

Issue8

eISSN2076-0817

DOIhttps://doi.org/10.3390/pathogens13080654

Web address https://doi.org/10.3390/pathogens13080654

Self-archived copy’s web addresshttps://research.utu.fi/converis/portal/detail/Publication/457762430


Abstract
Human beta-defensins are host defense peptides with broad antimicrobial and inflammatory functions. In the oral cavity, these peptides are produced mainly by the keratinocytes of the epithelium; however, fibroblasts, monocytes, and macrophages also contribute to oral human beta-defensin expressions. The resident and immune cells of the oral cavity come into contact with various microbe-associated molecular patterns continuously and simultaneously. The overall antimicrobial cellular response is highly influenced by local and environmental factors. Recent studies have produced evidence showing that not only systemic chronic diseases but also systemic factors like hyperglycemia, pregnancy, the long-term use of certain vitamins, and aging can modulate oral cellular antimicrobial responses against microbial challenges. Therefore, the aim of this narrative review is to discuss the role of systemic factors on oral human beta-defensin expressions.

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Funding information in the publication
This work was partly funded by the Finnish Dental Society Apollonia 2022-UKG, Minerva Foundation (Finland) 2023-UKG.


Last updated on 2025-27-01 at 18:33