A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Intermediate filaments at a glance
Tekijät: Coelho-Rato, Leila S.; Parvanian, Sepideh; Salajkova, Sarka Andrs; Medalia, Ohad; Eriksson, John E.
Kustantaja: The Company of Biologists
Julkaisuvuosi: 2024
Journal: Journal of Cell Science
Artikkelin numero: jcs261386
Vuosikerta: 137
Numero: 16
ISSN: 0021-9533
eISSN: 1477-9137
DOI: https://doi.org/10.1242/jcs.261386
Verkko-osoite: https://doi.org/10.1242/jcs.261386
Intermediate filaments (IFs) comprise a large family of versatile cytoskeletal proteins, divided into six subtypes with tissue-specific expression patterns. IFs have a wide repertoire of cellular functions, including providing structural support to cells, as well as active roles in mechanical support and signaling pathways. Consequently, defects in IFs are associated with more than 100 diseases. In this Cell Science at a Glance article, we discuss the established classes of IFs and their general features, their functions beyond structural support, and recent advances in the field. We also highlight their involvement in disease and potential use as clinical markers of pathological conditions. Finally, we provide our view on current knowledge gaps and the future directions of the IF field.
Julkaisussa olevat rahoitustiedot:
Our work in this area was supported by the Academy of Finland, Sigrid Jusélius Foundation, Jane and Aatos Erkko Foundation, Magnus Ehrnrooth Foundation, K. Albin Johanssons Stiftelse, Otto A. Malm Foundation, Finnish Cultural Foundation, Swedish Cultural Foundation, Ella and Georg Ehrnrooth Foundation, Emil Altonen, Instrumentarium Science Foundation and Swiss National Science Foundation (SNSF 310030_207453).
