A1 Refereed original research article in a scientific journal
Intermediate filaments at a glance
Authors: Coelho-Rato, Leila S.; Parvanian, Sepideh; Salajkova, Sarka Andrs; Medalia, Ohad; Eriksson, John E.
Publisher: The Company of Biologists
Publication year: 2024
Journal: Journal of Cell Science
Article number: jcs261386
Volume: 137
Issue: 16
ISSN: 0021-9533
eISSN: 1477-9137
DOI: https://doi.org/10.1242/jcs.261386
Web address : https://doi.org/10.1242/jcs.261386
Intermediate filaments (IFs) comprise a large family of versatile cytoskeletal proteins, divided into six subtypes with tissue-specific expression patterns. IFs have a wide repertoire of cellular functions, including providing structural support to cells, as well as active roles in mechanical support and signaling pathways. Consequently, defects in IFs are associated with more than 100 diseases. In this Cell Science at a Glance article, we discuss the established classes of IFs and their general features, their functions beyond structural support, and recent advances in the field. We also highlight their involvement in disease and potential use as clinical markers of pathological conditions. Finally, we provide our view on current knowledge gaps and the future directions of the IF field.
Funding information in the publication:
Our work in this area was supported by the Academy of Finland, Sigrid Jusélius Foundation, Jane and Aatos Erkko Foundation, Magnus Ehrnrooth Foundation, K. Albin Johanssons Stiftelse, Otto A. Malm Foundation, Finnish Cultural Foundation, Swedish Cultural Foundation, Ella and Georg Ehrnrooth Foundation, Emil Altonen, Instrumentarium Science Foundation and Swiss National Science Foundation (SNSF 310030_207453).
