A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Multikingdom oral microbiome interactions in early-onset cryptogenic ischemic stroke
Tekijät: Manzoor, Muhammed; Leskelä, Jaakko; Pietiäinen, Milla; Martinez-Majander, Nicolas; Ylikotila, Pauli; Könönen, Eija; Niiranen, Teemu; Lahti, Leo; Sinisalo, Juha; Putaala, Jukka; Pussinen, Pirkko J; Paju, Susanna
Kustantaja: Springer Nature; International Society for Microbial Ecology
Julkaisuvuosi: 2024
Journal: ISME Communications
Tietokannassa oleva lehden nimi: ISME communications
Lehden akronyymi: ISME Commun
Artikkelin numero: ycae088
Vuosikerta: 4
Numero: 1
eISSN: 2730-6151
DOI: https://doi.org/10.1093/ismeco/ycae088
Verkko-osoite: https://doi.org/10.1093/ismeco/ycae088
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/457191176
Although knowledge of the role of the oral microbiome in ischemic stroke is steadily increasing, little is known about the multikingdom microbiota interactions and their consequences. We enrolled participants from a prospective multicentre case-control study and investigated multikingdom microbiome differences using saliva metagenomic datasets (n = 308) from young patients diagnosed with cryptogenic ischemic stroke (CIS) and age- and sex-matched stroke-free controls. Differentially abundant taxa were identified using Analysis of Compositions of Microbiomes with Bias Correction (ANCOM-BC2). Functional potential was inferred using HUMANn3. Our findings revealed significant differences in the composition and functional capacity of the oral microbiota associated with CIS. We identified 51 microbial species, including 47 bacterial, 3 viral, and one fungal species associated with CIS in the adjusted model. Co-abundance network analysis highlighted a more intricate microbial network in CIS patients, indicating potential interactions and co-occurrence patterns among microbial species across kingdoms. The results of our metagenomic analysis reflect the complexity of the oral microbiome, with high diversity and multikingdom interactions, which may play a role in health and disease.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
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Open Access funding provided by University of Helsinki. This work was supported by the Academy of Finland grants (316777 and 355532 for S.P.; 340750 for P.J.P.), the Finnish Dental Society Apollonia (for P.J.P.), the Sigrid Jusélius Foundation (for P.J.P.), the Novo Nordisk Foundation (for P.J.P.) and the Minerva Foundation Selma and Maja-Lisa Selander’s Fund (for M.M.). The SECRETO study was funded by the Finnish Medical Foundation, the Academy of Finland (286246, 318075, 322656), the Helsinki and Uusimaa Hospital District (TYH2014407, TYH2018318), and the Sigrid Jusélius Foundation. The funders had no role in the design or execution of the study; the collection, management, analysis, or interpretation of data; the preparation, review, or approval of the manuscript; or the decision to submit the manuscript for publication.
