Connecting the dots : Computational network analysis for disease insight and drug repurposing
: Siminea, Nicoleta; Czeizler, Eugen; Popescu, Victor-Bogdan; Petre, Ion; Păun, Andrei
Publisher: Elsevier
: 2024
: Current Opinion in Structural Biology
: Current Opinion in Structural Biology
: 102881
: 88
: 0959-440X
: 1879-033X
DOI: https://doi.org/10.1016/j.sbi.2024.102881
: https://doi.org/10.1016/j.sbi.2024.102881
: https://research.utu.fi/converis/portal/detail/Publication/457188188
Network biology is a powerful framework for studying the structure, function, and dynamics of biological systems, offering insights into the balance between health and disease states. The field is seeing rapid progress in all of its aspects: data availability, network synthesis, network analytics, and impactful applications in medicine and drug development. We review the most recent and significant results in network biomedicine, with a focus on the latest data, analytics, software resources, and applications in medicine. We also discuss what in our view are the likely directions of impactful development over the next few years.
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This work was partially supported by the Core Program within the Romanian National Research, Development and Innovation Plan 2022–2027, carried out with the support of MRID, project no. 23020101(SIA-PRO), contract no 7N/2022, and project PNRR-I8 no. 842027778., contract no 760096.
