A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä
Type 1 Diabetes Mellitus and Host-Bacterial Interactions in the Oral Cavity
Tekijät: Gürsoy, Ulvi Kahraman; Yilmaz, Neslihan; Yilmaz, Dogukan; Grönroos, Sanni; Gürsoy, Mervi
Kustantaja: Elsevier
Julkaisuvuosi: 2024
Journal: Current Opinion in Endocrine and Metabolic Research
Tietokannassa oleva lehden nimi: Current Opinion in Endocrine and Metabolic Research
Artikkelin numero: 100536
Vuosikerta: 36
eISSN: 2451-9650
DOI: https://doi.org/10.1016/j.coemr.2024.100536
Verkko-osoite: https://doi.org/10.1016/j.coemr.2024.100536
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/456998932
Type 1 diabetes mellitus (T1DM) is an autoimmune disease which is characterized by the destruction of insulin producing pancreatic β-cells. Current evidence supports the contribution of T-cells, macrophages, B-cells, and dendritic cells to the pathogenesis of T1DM as well. T1DM-associated risk factors, including defects in host immune response, socioeconomic conditions and environmental factors create dysbiotic environment in the oral cavity, which support the growth of pathogenic microbial biofilms. Changes in microbial composition, together with the diminished immune response, lead to the development of two most common oral diseases, caries and periodontal diseases. In the present review, we summarized the current evidence on oral manifestations of T1DM, and described the shifts in oral microbial composition and oral immune response.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
Julkaisussa olevat rahoitustiedot:
This review is supported by Turku FINDOS doctoral program, by Minerva Foundation, Finland, by The Diabetes Research Foundations, Finland, and by SHS Apollonia, Finland.
