A2 Refereed review article in a scientific journal
Type 1 Diabetes Mellitus and Host-Bacterial Interactions in the Oral Cavity
Authors: Gürsoy, Ulvi Kahraman; Yilmaz, Neslihan; Yilmaz, Dogukan; Grönroos, Sanni; Gürsoy, Mervi
Publisher: Elsevier
Publication year: 2024
Journal: Current Opinion in Endocrine and Metabolic Research
Journal name in source: Current Opinion in Endocrine and Metabolic Research
Article number: 100536
Volume: 36
eISSN: 2451-9650
DOI: https://doi.org/10.1016/j.coemr.2024.100536
Web address : https://doi.org/10.1016/j.coemr.2024.100536
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/456998932
Type 1 diabetes mellitus (T1DM) is an autoimmune disease which is characterized by the destruction of insulin producing pancreatic β-cells. Current evidence supports the contribution of T-cells, macrophages, B-cells, and dendritic cells to the pathogenesis of T1DM as well. T1DM-associated risk factors, including defects in host immune response, socioeconomic conditions and environmental factors create dysbiotic environment in the oral cavity, which support the growth of pathogenic microbial biofilms. Changes in microbial composition, together with the diminished immune response, lead to the development of two most common oral diseases, caries and periodontal diseases. In the present review, we summarized the current evidence on oral manifestations of T1DM, and described the shifts in oral microbial composition and oral immune response.
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Funding information in the publication:
This review is supported by Turku FINDOS doctoral program, by Minerva Foundation, Finland, by The Diabetes Research Foundations, Finland, and by SHS Apollonia, Finland.
