Rhinovirus C Is Associated With Severe Wheezing and Febrile Respiratory Illness in Young Children

: Erkkola Riku, Turunen Riitta, Räisänen Kati, Waris Matti, Vuorinen Tytti, Laine Miia, Tähtinen Paula, Gern James E., Bochkov Yury A., Ruohola Aino, Jartti Tuomas

Publisher: Williams & Wilkins

: 2020

: Pediatric Infectious Disease Journal

: The Pediatric infectious disease journal

: Pediatr Infect Dis J

: 39

: 4

: 283

: 286

: 0891-3668

: 1532-0987

DOI: https://doi.org/10.1097/INF.0000000000002570

: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749725/

Background:
Rhinovirus is the most common virus causing respiratory tract illnesses in children. Rhinoviruses are classified into species A, B and C. We examined the associations between different rhinovirus species and respiratory illness severity.
Methods:
This is a retrospective observational cohort study on confirmed rhinovirus infections in 134 children 3–23 months of age, who were enrolled in 2 prospective studies on bronchiolitis and acute otitis media, respectively, conducted simultaneously in Turku University Hospital, Turku, Finland, between September 2007 and December 2008.
Results:
Rhinovirus C is the most prevalent species in our study, and it was associated with severe wheezing and febrile illness. We also noted that history of atopic eczema was associated with wheezing.
Conclusions:
Our understanding of rhinovirus C as the most pathogenic rhinovirus species was fortified. Existing research supports the idea that atopic characteristics are associated with the severity of the rhinovirus C-induced illness.