Synthesis of Organometallic Oligonucleotides through Oximation with Metalated Benzaldehydes

: Maity S.K., Lönnberg T.A.

Publisher: AMER CHEMICAL SOC

: 2019

: ACS Omega

: ACS OMEGA

: 4

: 20

: 18803

: 18808

: 6

: 2470-1343

DOI: https://doi.org/10.1021/acsomega.9b02804

: https://research.utu.fi/converis/portal/detail/Publication/44064800

A phthaloyl-protected aminooxymethyl-C-2'-deoxyriboside building block has been prepared and incorporated in the middle of an oligodeoxyribonucleotide. Removal of the phthaloyl protection followed by on-support oximation with either mercurated or palladated benzaldehydes yielded oligonucleotides bearing the respective benzaldoxime metallacycles.

acsomega.9b02804.pdf