Radiolabeled porous silicon for bioimaging applications

: Airaksinen AJ

: Santos HA

Publisher: WOODHEAD PUBL LTD, ABINGTON HALL ABINGTON, CAMBRIDGE CB1 6AH, CAMBS, ENGLAND

: 2014

: Woodhead Publishing series in biomaterials

: Porous Silicon for Biomedical Applications

: POROUS SILICON FOR BIOMEDICAL APPLICATIONS

: WOODH PUBL SER BIOM

: 68

: 253

: 269

: 17

: 978-0-85709-711-8

: 2049-9485

DOI: https://doi.org/10.1533/9780857097156.2.253

Nuclear imaging can provide detailed knowledge of nanoparticle mediated drug delivery by allowing follow-up of the drug carrier biodistribution and the carrier behavior in the body. Positron emission tomography (PET) and single-photon emission computed tomography (SPECT) are highly sensitive and non-invasive imaging modalities that have the ability to accurately localize and quantify the carrier biodistribution and accumulation, regardless of the tissue depth. In this chapter, the principles of PET and SPECT will be briefly discussed. The chapter will give a concise review on the methods for preparing radiolabeled porous silicon (PSi) particles for nuclear imaging, and on how these radiolabeled particles have been applied in the evaluation of PSi based drug delivery systems.