A3 Refereed book chapter or chapter in a compilation book
Radiolabeled porous silicon for bioimaging applications
Authors: Airaksinen AJ
Editors: Santos HA
Publisher: WOODHEAD PUBL LTD, ABINGTON HALL ABINGTON, CAMBRIDGE CB1 6AH, CAMBS, ENGLAND
Publication year: 2014
Journal: Woodhead Publishing series in biomaterials
Book title : Porous Silicon for Biomedical Applications
Journal name in source: POROUS SILICON FOR BIOMEDICAL APPLICATIONS
Journal acronym: WOODH PUBL SER BIOM
Volume: 68
First page : 253
Last page: 269
Number of pages: 17
ISBN: 978-0-85709-711-8
ISSN: 2049-9485
DOI: https://doi.org/10.1533/9780857097156.2.253
Abstract
Nuclear imaging can provide detailed knowledge of nanoparticle mediated drug delivery by allowing follow-up of the drug carrier biodistribution and the carrier behavior in the body. Positron emission tomography (PET) and single-photon emission computed tomography (SPECT) are highly sensitive and non-invasive imaging modalities that have the ability to accurately localize and quantify the carrier biodistribution and accumulation, regardless of the tissue depth. In this chapter, the principles of PET and SPECT will be briefly discussed. The chapter will give a concise review on the methods for preparing radiolabeled porous silicon (PSi) particles for nuclear imaging, and on how these radiolabeled particles have been applied in the evaluation of PSi based drug delivery systems.
Nuclear imaging can provide detailed knowledge of nanoparticle mediated drug delivery by allowing follow-up of the drug carrier biodistribution and the carrier behavior in the body. Positron emission tomography (PET) and single-photon emission computed tomography (SPECT) are highly sensitive and non-invasive imaging modalities that have the ability to accurately localize and quantify the carrier biodistribution and accumulation, regardless of the tissue depth. In this chapter, the principles of PET and SPECT will be briefly discussed. The chapter will give a concise review on the methods for preparing radiolabeled porous silicon (PSi) particles for nuclear imaging, and on how these radiolabeled particles have been applied in the evaluation of PSi based drug delivery systems.
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