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Radiolabeled porous silicon for bioimaging applications
Tekijät: Airaksinen AJ
Toimittaja: Santos HA
Kustantaja: WOODHEAD PUBL LTD, ABINGTON HALL ABINGTON, CAMBRIDGE CB1 6AH, CAMBS, ENGLAND
Julkaisuvuosi: 2014
Journal: Woodhead Publishing series in biomaterials
Kokoomateoksen nimi: Porous Silicon for Biomedical Applications
Tietokannassa oleva lehden nimi: POROUS SILICON FOR BIOMEDICAL APPLICATIONS
Lehden akronyymi: WOODH PUBL SER BIOM
Vuosikerta: 68
Aloitussivu: 253
Lopetussivu: 269
Sivujen määrä: 17
ISBN: 978-0-85709-711-8
ISSN: 2049-9485
DOI: https://doi.org/10.1533/9780857097156.2.253
Tiivistelmä
Nuclear imaging can provide detailed knowledge of nanoparticle mediated drug delivery by allowing follow-up of the drug carrier biodistribution and the carrier behavior in the body. Positron emission tomography (PET) and single-photon emission computed tomography (SPECT) are highly sensitive and non-invasive imaging modalities that have the ability to accurately localize and quantify the carrier biodistribution and accumulation, regardless of the tissue depth. In this chapter, the principles of PET and SPECT will be briefly discussed. The chapter will give a concise review on the methods for preparing radiolabeled porous silicon (PSi) particles for nuclear imaging, and on how these radiolabeled particles have been applied in the evaluation of PSi based drug delivery systems.
Nuclear imaging can provide detailed knowledge of nanoparticle mediated drug delivery by allowing follow-up of the drug carrier biodistribution and the carrier behavior in the body. Positron emission tomography (PET) and single-photon emission computed tomography (SPECT) are highly sensitive and non-invasive imaging modalities that have the ability to accurately localize and quantify the carrier biodistribution and accumulation, regardless of the tissue depth. In this chapter, the principles of PET and SPECT will be briefly discussed. The chapter will give a concise review on the methods for preparing radiolabeled porous silicon (PSi) particles for nuclear imaging, and on how these radiolabeled particles have been applied in the evaluation of PSi based drug delivery systems.
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