A2 Refereed review article in a scientific journal
Host poly(ADP-ribose) polymerases (PARPs) in acute and chronic bacterial infections
Authors: Moona Miettinen, Madhukar Vedanthama, Arto T. Pulliainen
Publisher: Elsevier Masson SAS
Publication year: 2019
Journal: Microbes and Infection
Journal name in source: Microbes and Infection
Volume: 21
Issue: 10
First page : 423
Last page: 431
Number of pages: 9
ISSN: 1286-4579
eISSN: 1769-714X
DOI: https://doi.org/10.1016/j.micinf.2019.06.002
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/41661251
Abstract
Protein
ADP-ribosylation is a reversible post-translational modification, which
alters protein activity, localization, interactome or stability,
leading to perturbation of cell signaling. This review summarizes the
emerging data indicating that host cell ADP-ribosylating enzymes,
poly(ADP-ribose) polymerases (PARPs), influence the course of a
bacterial infection, in parallel to ADP-ribosylating bacterial toxins.
Host cell PARP targeting could be an efficient therapeutic approach to
treat certain bacterial infections, possibly by repurposing the approved
or clinical trial PARP inhibitors developed for cancer therapy.
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