A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä
Host poly(ADP-ribose) polymerases (PARPs) in acute and chronic bacterial infections
Tekijät: Moona Miettinen, Madhukar Vedanthama, Arto T. Pulliainen
Kustantaja: Elsevier Masson SAS
Julkaisuvuosi: 2019
Journal: Microbes and Infection
Tietokannassa oleva lehden nimi: Microbes and Infection
Vuosikerta: 21
Numero: 10
Aloitussivu: 423
Lopetussivu: 431
Sivujen määrä: 9
ISSN: 1286-4579
eISSN: 1769-714X
DOI: https://doi.org/10.1016/j.micinf.2019.06.002
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/41661251
Abstract
Protein
ADP-ribosylation is a reversible post-translational modification, which
alters protein activity, localization, interactome or stability,
leading to perturbation of cell signaling. This review summarizes the
emerging data indicating that host cell ADP-ribosylating enzymes,
poly(ADP-ribose) polymerases (PARPs), influence the course of a
bacterial infection, in parallel to ADP-ribosylating bacterial toxins.
Host cell PARP targeting could be an efficient therapeutic approach to
treat certain bacterial infections, possibly by repurposing the approved
or clinical trial PARP inhibitors developed for cancer therapy.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
