B1 Vertaisarvioimaton kirjoitus tieteellisessä lehdessä
No Link Between Striatal Dopaminergic Axons and Dopamine Transporter Imagingin Parkinson’s Disease
Tekijät: Honkanen Emma A., Saari Laura, Orte Katri, Gardberg Maria, Noponen Tommi, Joutsa Juho, Kaasinen Valtteri
Kustantaja: Wiley-Blackwell Publishing Ltd.
Julkaisuvuosi: 2019
Journal: Movement Disorders
Vuosikerta: 34
Numero: 10
Aloitussivu: 1562
Lopetussivu: 1566
Sivujen määrä: 5
ISSN: 0885-3185
eISSN: 1531-8257
DOI: https://doi.org/10.1002/mds.27777
Verkko-osoite: 10.1002/mds.27777
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/41652649
Background:Brain dopamine transporter binding hasbeen considered a possible biomarker for nigrostriataldegeneration in PD.Objective:To investigate whether dopamine trans-porter binding is associated with the number of dopa-minergic neurites in the putamen.
Methods:Tyrosine hydroxylase–positive nervefiberswere counted from postmortem putamen sections takenfrom 14 parkinsonism patients who had been scannedwith dopamine transporter single-photon emission com-puted tomography antemortem. Fiber counts were cor-related with putamen dopamine transporter binding andSN neuron counts.
Results:The putamen dopamine transporter specificbinding ratio did not correlate with the putamen tyrosinehydroxylase–positive axon counts (r = 0.00;P= 1.0; PDpatients: r = 0.07;P= 0.86). The nigra neuron counts had a positive correlation with the putamen tyrosinehydroxylase–positive axon counts.
Conclusions:Striatal dopamine transporter imagingdoes not associate with axonal nor somal loss of thenigrostriatal neurons in PD. It may reflect dopaminergicactivity rather than number of surviving neurons or theirstriatal projection axons.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
