B1 Non-refereed article in a scientific journal
No Link Between Striatal Dopaminergic Axons and Dopamine Transporter Imagingin Parkinson’s Disease
Authors: Honkanen Emma A., Saari Laura, Orte Katri, Gardberg Maria, Noponen Tommi, Joutsa Juho, Kaasinen Valtteri
Publisher: Wiley-Blackwell Publishing Ltd.
Publication year: 2019
Journal: Movement Disorders
Volume: 34
Issue: 10
First page : 1562
Last page: 1566
Number of pages: 5
ISSN: 0885-3185
eISSN: 1531-8257
DOI: https://doi.org/10.1002/mds.27777
Web address : 10.1002/mds.27777
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/41652649
Background:Brain dopamine transporter binding hasbeen considered a possible biomarker for nigrostriataldegeneration in PD.Objective:To investigate whether dopamine trans-porter binding is associated with the number of dopa-minergic neurites in the putamen.
Methods:Tyrosine hydroxylase–positive nervefiberswere counted from postmortem putamen sections takenfrom 14 parkinsonism patients who had been scannedwith dopamine transporter single-photon emission com-puted tomography antemortem. Fiber counts were cor-related with putamen dopamine transporter binding andSN neuron counts.
Results:The putamen dopamine transporter specificbinding ratio did not correlate with the putamen tyrosinehydroxylase–positive axon counts (r = 0.00;P= 1.0; PDpatients: r = 0.07;P= 0.86). The nigra neuron counts had a positive correlation with the putamen tyrosinehydroxylase–positive axon counts.
Conclusions:Striatal dopamine transporter imagingdoes not associate with axonal nor somal loss of thenigrostriatal neurons in PD. It may reflect dopaminergicactivity rather than number of surviving neurons or theirstriatal projection axons.
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