68Ga-DOTA-E[c(RGDfK)]2 Positron Emission Tomography Imaging of SHARPIN-Regulated Integrin Activity in Mice



: Riikka Siitonen, Emilia Peuhu, Anu K Autio, Heidi Liljenbäck, Elina Mattila, Olli Metsälä, Meeri Käkelä, Tiina Saanijoki, Ingrid Dijkgraaf, Sirpa Jalkanen, Johanna Ivaska, Anne Roivainen

: 2019

: Journal of Nuclear Medicine

: Journal of nuclear medicine : official publication, Society of Nuclear Medicine

: J Nucl Med

: 60

: 10

: 1380

: 1387

: 8

: 0161-5505

: 1535-5667

DOI: https://doi.org/10.2967/jnumed.118.222026

: https://research.utu.fi/converis/portal/detail/Publication/41392288


Sharpincpdm mice demonstrated increased integrin activity and vascularization in B16-F10-luc melanoma tumors, as demonstrated by RGD-based in vivo PET imaging. These data indicate that SHARPIN, a protein previously associated with increased cancer growth and metastasis, may also have important regulatory roles in controlling the tumor microenvironment.

Last updated on 2024-26-11 at 15:09