A1 Refereed original research article in a scientific journal

68Ga-DOTA-E[c(RGDfK)]2 Positron Emission Tomography Imaging of SHARPIN-Regulated Integrin Activity in Mice



Authors: Riikka Siitonen, Emilia Peuhu, Anu K Autio, Heidi Liljenbäck, Elina Mattila, Olli Metsälä, Meeri Käkelä, Tiina Saanijoki, Ingrid Dijkgraaf, Sirpa Jalkanen, Johanna Ivaska, Anne Roivainen

Publication year: 2019

Journal: Journal of Nuclear Medicine

Journal name in source: Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Journal acronym: J Nucl Med

Volume: 60

Issue: 10

First page : 1380

Last page: 1387

Number of pages: 8

ISSN: 0161-5505

eISSN: 1535-5667

DOI: https://doi.org/10.2967/jnumed.118.222026

Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/41392288


Abstract
Sharpincpdm mice demonstrated increased integrin activity and vascularization in B16-F10-luc melanoma tumors, as demonstrated by RGD-based in vivo PET imaging. These data indicate that SHARPIN, a protein previously associated with increased cancer growth and metastasis, may also have important regulatory roles in controlling the tumor microenvironment.

Downloadable publication

This is an electronic reprint of the original article.
This reprint may differ from the original in pagination and typographic detail. Please cite the original version.


Last updated on 2024-26-11 at 15:09