Youth and Long-Term Dietary Calcium Intake With Risk of Impaired Glucose Metabolism and Type 2 Diabetes in Adulthood
: Feitong Wu, Markus Juonala, Katja Pahkala, Marie-Jeanne Buscot, Matthew A Sabin, Niina Pitkänen, Tapani Rönnemaa, Antti Jula, Terho Lehtimäki, Nina Hutri-Kähönen, Mika Kähönen, Tomi Laitinen,Jorma S A Viikari, Olli T Raitakari, Costan G Magnussen
Publisher: Oxford Academic
: 2019
: Journal of Clinical Endocrinology and Metabolism
: The Journal of clinical endocrinology and metabolism
: JCEM
: 104
: 6
: 2067
: 2074
: 8
: 1945-7197
: 1945-7197
DOI: https://doi.org/10.1210/jc.2018-02321
: https://research.utu.fi/converis/portal/detail/Publication/40459439
CONTEXT:
To the best of our knowledge, no previous studies have examined the role of youth calcium intake in the development of impaired glucose metabolism, especially those with long-term high calcium intake.
OBJECTIVES:To examine whether youth and long-term (between youth and adulthood) dietary calcium intake is associated with adult impaired glucose metabolism and type 2 diabetes (T2D).
DESIGN, SETTING, AND PARTICIPANTS:The Cardiovascular Risk in Young Finns Study is a 31-year prospective cohort study (n = 1134; age, 3 to 18 years at baseline).
EXPOSURES:Dietary calcium intake was assessed at baseline (1980) and adult follow-up visits (2001, 2007, and 2011). Long-term (mean between youth and adulthood) dietary calcium intake was calculated.
MAIN OUTCOME MEASURES:Adult impaired fasting glucose (IFG) and T2D.
RESULTS:We found no evidence for nonlinear associations between calcium intake and IFG or T2D among females and males (all P for nonlinearity > 0.05). Higher youth and long-term dietary calcium intake was not associated with the risk of IFG or T2D among females or males after adjustment for confounders, including youth and adult body mass index.
CONCLUSIONS:Youth or long-term dietary calcium intake is not associated with adult risk of developing impaired glucose metabolism or T2D.
