Plasma Heme Scavengers Alpha-l-Microglobulin and Hemopexin as Biomarkers in High-Risk Pregnancies



: Grigorios Kalapotharakos, Katja Murtoniemi, Bo Åkerström, Esa Hämäläinen, Eero Kajantie, Katri Räikkönen, Pia Villa, Hannele Laivuori, Stefan R. Hansson

Publisher: FRONTIERS MEDIA SA

: 2019

: Frontiers in Physiology

: FRONTIERS IN PHYSIOLOGY

: FRONT PHYSIOL

: ARTN 300

: 10

: 7

: 1664-042X

DOI: https://doi.org/10.3389/fphys.2019.00300

: https://research.utu.fi/converis/portal/detail/Publication/40090857


Women with established preeclampsia (PE) have increased plasma concentration of free fetal hemoglobin. We measured two hemoglobin scavenger system proteins, hemopexin (Hpx) and alpha-1 -microglobulin (A1M) in maternal plasma using enzyme-linked immunosorbent assay during the late second trimester of pregnancy in women with high and low risk of developing PE. In total 142 women were included in nested case-control study: 42 women diagnosed with PE and 100 controls (49 randomly selected high-risk and 51 low-risk controls). The concentration of plasma A1M in high-risk controls was higher compared to low-risk controls. Women with severe PE had higher plasma A1M levels compared to women with non-severe PE. In conclusion, the concentration of plasma A1M is increased in the late second trimester in high-risk controls, suggesting activation of endogenous protective system against oxidative stress.

Last updated on 2024-26-11 at 12:07