A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Plasma Heme Scavengers Alpha-l-Microglobulin and Hemopexin as Biomarkers in High-Risk Pregnancies
Tekijät: Grigorios Kalapotharakos, Katja Murtoniemi, Bo Åkerström, Esa Hämäläinen, Eero Kajantie, Katri Räikkönen, Pia Villa, Hannele Laivuori, Stefan R. Hansson
Kustantaja: FRONTIERS MEDIA SA
Julkaisuvuosi: 2019
Journal: Frontiers in Physiology
Tietokannassa oleva lehden nimi: FRONTIERS IN PHYSIOLOGY
Lehden akronyymi: FRONT PHYSIOL
Artikkelin numero: ARTN 300
Vuosikerta: 10
Sivujen määrä: 7
ISSN: 1664-042X
DOI: https://doi.org/10.3389/fphys.2019.00300
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/40090857
Women with established preeclampsia (PE) have increased plasma concentration of free fetal hemoglobin. We measured two hemoglobin scavenger system proteins, hemopexin (Hpx) and alpha-1 -microglobulin (A1M) in maternal plasma using enzyme-linked immunosorbent assay during the late second trimester of pregnancy in women with high and low risk of developing PE. In total 142 women were included in nested case-control study: 42 women diagnosed with PE and 100 controls (49 randomly selected high-risk and 51 low-risk controls). The concentration of plasma A1M in high-risk controls was higher compared to low-risk controls. Women with severe PE had higher plasma A1M levels compared to women with non-severe PE. In conclusion, the concentration of plasma A1M is increased in the late second trimester in high-risk controls, suggesting activation of endogenous protective system against oxidative stress.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
