Overexpression and nuclear translocation of hypoxia-inducible factor prolyl hydroxylase PHD2 in head and neck squamous cell carcinoma is associated with tumor aggressiveness



: Jokilehto T, Rantanen K, Luukkaa M, Heikkinen P, Grenman R, Minn H, Kronqvist P, Jaakkola PM

Publisher: AMER ASSOC CANCER RESEARCH

: 2006

Clinical Cancer Research

CLINICAL CANCER RESEARCH

: CLIN CANCER RES

: 12

: 4

: 1080

: 1087

: 8

: 1078-0432

DOI: https://doi.org/10.1158/1078-0432.CCR-05-2022


Conclusions: Our results show that increased levels and nuclear translocation of the cellular oxygen sensor, PHD2, are associated with less differentiated and strongly proliferating tumors. Furthermore, they imply that even the elevated PHD2 levels are not sufficient to down-regulate HIF-1 alpha in some tumors.



Last updated on 2025-14-10 at 09:55