A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Overexpression and nuclear translocation of hypoxia-inducible factor prolyl hydroxylase PHD2 in head and neck squamous cell carcinoma is associated with tumor aggressiveness
Tekijät: Jokilehto T, Rantanen K, Luukkaa M, Heikkinen P, Grenman R, Minn H, Kronqvist P, Jaakkola PM
Kustantaja: AMER ASSOC CANCER RESEARCH
Julkaisuvuosi: 2006
Lehti:: Clinical Cancer Research
Tietokannassa oleva lehden nimi: CLINICAL CANCER RESEARCH
Lehden akronyymi: CLIN CANCER RES
Vuosikerta: 12
Numero: 4
Aloitussivu: 1080
Lopetussivu: 1087
Sivujen määrä: 8
ISSN: 1078-0432
DOI: https://doi.org/10.1158/1078-0432.CCR-05-2022
Tiivistelmä
Conclusions: Our results show that increased levels and nuclear translocation of the cellular oxygen sensor, PHD2, are associated with less differentiated and strongly proliferating tumors. Furthermore, they imply that even the elevated PHD2 levels are not sufficient to down-regulate HIF-1 alpha in some tumors.
Conclusions: Our results show that increased levels and nuclear translocation of the cellular oxygen sensor, PHD2, are associated with less differentiated and strongly proliferating tumors. Furthermore, they imply that even the elevated PHD2 levels are not sufficient to down-regulate HIF-1 alpha in some tumors.
Turun yliopiston Tutkimustietojärjestelmän portaali