A1 Refereed original research article in a scientific journal
Overexpression and nuclear translocation of hypoxia-inducible factor prolyl hydroxylase PHD2 in head and neck squamous cell carcinoma is associated with tumor aggressiveness
Authors: Jokilehto T, Rantanen K, Luukkaa M, Heikkinen P, Grenman R, Minn H, Kronqvist P, Jaakkola PM
Publisher: AMER ASSOC CANCER RESEARCH
Publication year: 2006
Journal:: Clinical Cancer Research
Journal name in source: CLINICAL CANCER RESEARCH
Journal acronym: CLIN CANCER RES
Volume: 12
Issue: 4
First page : 1080
Last page: 1087
Number of pages: 8
ISSN: 1078-0432
DOI: https://doi.org/10.1158/1078-0432.CCR-05-2022
Abstract
Conclusions: Our results show that increased levels and nuclear translocation of the cellular oxygen sensor, PHD2, are associated with less differentiated and strongly proliferating tumors. Furthermore, they imply that even the elevated PHD2 levels are not sufficient to down-regulate HIF-1 alpha in some tumors.
Conclusions: Our results show that increased levels and nuclear translocation of the cellular oxygen sensor, PHD2, are associated with less differentiated and strongly proliferating tumors. Furthermore, they imply that even the elevated PHD2 levels are not sufficient to down-regulate HIF-1 alpha in some tumors.
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