Enhanced osteoblastic differentiation and bone formation in co-culture of human bone marrow mesenchymal stromal cells and peripheral blood mononuclear cells with exogenous VEGF



: Joensuu K, Uusitalo L, Alm JJ, Aro HT, Hentunen TA, Heino TJ

Publisher: ELSEVIER MASSON

: 2015

 Orthopaedics and Traumatology: Surgery and Research

: ORTHOPAEDICS & TRAUMATOLOGY-SURGERY & RESEARCH

: ORTHOP TRAUMATOL-SUR

: 101

: 3

: 381

: 386

: 6

: 1877-0568

DOI: https://doi.org/10.1016/j.otsr.2015.01.014


Conclusion: Our study demonstrates that the in vitro ALP activity and mineralization of human BM-MSCs is more efficient in the presence of PB-MNCs, and exogenously added VEGF further enhances the stimulatory effect. This indicates that PB-MNCs could be a potential cell source in development of co-culture systems for novel tissue engineering applications for enhanced bone healing. (C) 2015 Elsevier Masson SAS. All rights reserved.




Mesenchymal stromal cells, Mononuclear cells, Osteoblastic differentiation, Tissue engineering, Vascular endothelial growth factor



Last updated on 26/11/2024 09:05:00 PM