Enhanced osteoblastic differentiation and bone formation in co-culture of human bone marrow mesenchymal stromal cells and peripheral blood mononuclear cells with exogenous VEGF



: Joensuu K, Uusitalo L, Alm JJ, Aro HT, Hentunen TA, Heino TJ

Publisher: ELSEVIER MASSON

: 2015

: Orthopaedics and Traumatology: Surgery and Research

: ORTHOPAEDICS & TRAUMATOLOGY-SURGERY & RESEARCH

: ORTHOP TRAUMATOL-SUR

: 101

: 3

: 381

: 386

: 6

: 1877-0568

DOI: https://doi.org/10.1016/j.otsr.2015.01.014


Conclusion: Our study demonstrates that the in vitro ALP activity and mineralization of human BM-MSCs is more efficient in the presence of PB-MNCs, and exogenously added VEGF further enhances the stimulatory effect. This indicates that PB-MNCs could be a potential cell source in development of co-culture systems for novel tissue engineering applications for enhanced bone healing. (C) 2015 Elsevier Masson SAS. All rights reserved.




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