Enhanced osteoblastic differentiation and bone formation in co-culture of human bone marrow mesenchymal stromal cells and peripheral blood mononuclear cells with exogenous VEGF - UTU Tutkimustietojärjestelmä

A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä

Enhanced osteoblastic differentiation and bone formation in co-culture of human bone marrow mesenchymal stromal cells and peripheral blood mononuclear cells with exogenous VEGF

Tekijät: Joensuu K, Uusitalo L, Alm JJ, Aro HT, Hentunen TA, Heino TJ

Julkaisuvuosi: 2015

Lehti: Orthopaedics and Traumatology: Surgery and Research

Tietokannassa oleva lehden nimi: ORTHOPAEDICS & TRAUMATOLOGY-SURGERY & RESEARCH

Lehden akronyymi: ORTHOP TRAUMATOL-SUR

Vuosikerta: 101

Numero: 3

Aloitussivu: 381

Lopetussivu: 386

Sivujen määrä: 6

ISSN: 1877-0568

DOI: https://doi.org/10.1016/j.otsr.2015.01.014

Tiivistelmä

Conclusion: Our study demonstrates that the in vitro ALP activity and mineralization of human BM-MSCs is more efficient in the presence of PB-MNCs, and exogenously added VEGF further enhances the stimulatory effect. This indicates that PB-MNCs could be a potential cell source in development of co-culture systems for novel tissue engineering applications for enhanced bone healing. (C) 2015 Elsevier Masson SAS. All rights reserved.