A4 Vertaisarvioitu artikkeli konferenssijulkaisussa
Enhanced bioavailability of peptide YY using nanoporous silicon as a drug carrier
Tekijät: Kovalainen M., Mönkäre J., Mäkilä E., Salonen J., Lehto V., Herzig K., Järvinen K.
Toimittaja: Laudon M, Romanowicz B
Konferenssin vakiintunut nimi: NSTI Nanotechnology Conference and Expo
Julkaisuvuosi: 2011
Kokoomateoksen nimi: Nanotechnology 2011: Bio Sensors, Instruments, Medical, Environment and Energy
Tietokannassa oleva lehden nimi: Technical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011
Vuosikerta: 3
Aloitussivu: 322
Lopetussivu: 325
Sivujen määrä: 4
ISBN: 978-1-4398-7138-6
Verkko-osoite: https://briefs.techconnect.org/papers/enhanced-bioavailability-of-peptide-yy-using-nanoporous-silicon-as-a-drug-carrier/
In the present study, we have used nanoporous silicon microparticles as drug carriers to improve anti-obesity peptide YY3-36 (PYY) delivery. Three different surface chemistries were used and PYY plasma concentrations were analyzed after subcutaneous injections as a function of time. Sustained release of PYY was obtained with all the three surface chemistries, but with a thermally oxidized surface, 2.5-fold increase in bioavailability was observed. Terminal half-lives were also significantly changed from the initial 25 min of PYY solution up to 21 h indicating a strong influence of PSi carriers on the in vivo pharmacokinetics of PYY.
