A4 Refereed article in a conference publication
Enhanced bioavailability of peptide YY using nanoporous silicon as a drug carrier
Authors: Kovalainen M., Mönkäre J., Mäkilä E., Salonen J., Lehto V., Herzig K., Järvinen K.
Editors: Laudon M, Romanowicz B
Conference name: NSTI Nanotechnology Conference and Expo
Publication year: 2011
Book title : Nanotechnology 2011: Bio Sensors, Instruments, Medical, Environment and Energy
Journal name in source: Technical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011
Volume: 3
First page : 322
Last page: 325
Number of pages: 4
ISBN: 978-1-4398-7138-6
Web address : https://briefs.techconnect.org/papers/enhanced-bioavailability-of-peptide-yy-using-nanoporous-silicon-as-a-drug-carrier/(external)
In the present study, we have used nanoporous silicon microparticles as drug carriers to improve anti-obesity peptide YY3-36 (PYY) delivery. Three different surface chemistries were used and PYY plasma concentrations were analyzed after subcutaneous injections as a function of time. Sustained release of PYY was obtained with all the three surface chemistries, but with a thermally oxidized surface, 2.5-fold increase in bioavailability was observed. Terminal half-lives were also significantly changed from the initial 25 min of PYY solution up to 21 h indicating a strong influence of PSi carriers on the in vivo pharmacokinetics of PYY.
