A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Cognitive Effects of White Matter Pathology in Normal and Pathological Aging
Tekijät: Kaskikallio A., Karrasch M., Rinne J.O., Tuokkola T., Parkkola R., Grönholm-Nyman P.
Kustantaja: IOS PRESS
Julkaisuvuosi: 2019
Journal: Journal of Alzheimer's Disease
Tietokannassa oleva lehden nimi: JOURNAL OF ALZHEIMERS DISEASE
Lehden akronyymi: J ALZHEIMERS DIS
Vuosikerta: 67
Numero: 2
Aloitussivu: 489
Lopetussivu: 493
Sivujen määrä: 5
ISSN: 1387-2877
DOI: https://doi.org/10.3233/JAD-180554
Verkko-osoite: https://content.iospress.com/articles/journal-of-alzheimers-disease/jad180554
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/39535018
We examined whether cerebrovascular white matter pathology is related to cognition as measured by the compound score of CERAD neuropsychological battery in cognitively normal older adults, patients with mild cognitive impairment, and patients with Alzheimer's disease (total n = 149), controlling for age and education. Trend-level effects of white matter pathology on cognition were only observed in patients with Alzheimer's disease (p = 0.062, eta(2) = 0.052), patients with severe frontal white matter pathology performed notably worse than those with milder pathology. This indicates that frontal cerebrovascular pathology may have an additive negative effect on cognition in Alzheimer's disease.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
