A1 Refereed original research article in a scientific journal
Cognitive Effects of White Matter Pathology in Normal and Pathological Aging
Authors: Kaskikallio A., Karrasch M., Rinne J.O., Tuokkola T., Parkkola R., Grönholm-Nyman P.
Publisher: IOS PRESS
Publication year: 2019
Journal: Journal of Alzheimer's Disease
Journal name in source: JOURNAL OF ALZHEIMERS DISEASE
Journal acronym: J ALZHEIMERS DIS
Volume: 67
Issue: 2
First page : 489
Last page: 493
Number of pages: 5
ISSN: 1387-2877
DOI: https://doi.org/10.3233/JAD-180554
Web address : https://content.iospress.com/articles/journal-of-alzheimers-disease/jad180554
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/39535018
We examined whether cerebrovascular white matter pathology is related to cognition as measured by the compound score of CERAD neuropsychological battery in cognitively normal older adults, patients with mild cognitive impairment, and patients with Alzheimer's disease (total n = 149), controlling for age and education. Trend-level effects of white matter pathology on cognition were only observed in patients with Alzheimer's disease (p = 0.062, eta(2) = 0.052), patients with severe frontal white matter pathology performed notably worse than those with milder pathology. This indicates that frontal cerebrovascular pathology may have an additive negative effect on cognition in Alzheimer's disease.
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