Monoacylglycerol lipase inhibitor JZL184 reduces neuroinflammatory response in APdE9 mice and in adult mouse glial cells



: Pihlaja R, Takkinen J, Eskola O, Vasara J, Lopez-Picon FR, Haaparanta-Solin M, Rinne JO

Publisher: BIOMED CENTRAL LTD

: 2015

 Journal of Neuroinflammation

: JOURNAL OF NEUROINFLAMMATION

: J NEUROINFLAMM

: ARTN 81

: 12

: 6

: 1742-2094

: 1742-2094

DOI: https://doi.org/10.1186/s12974-015-0305-9


Conclusions: JZL184 decreased the proinflammatory reactions of microglia and reduced the total A beta burden and its precursors in the APdE9 mouse model. It also reduced the proinflammatory responses of microglia and astrocytes isolated from adult mice.




Alzheimer's disease, Monoacylglycerol lipase, Neuroinflammation

Last updated on 26/11/2024 07:41:06 PM