Monoacylglycerol lipase inhibitor JZL184 reduces neuroinflammatory response in APdE9 mice and in adult mouse glial cells

: Pihlaja R, Takkinen J, Eskola O, Vasara J, Lopez-Picon FR, Haaparanta-Solin M, Rinne JO

Publisher: BIOMED CENTRAL LTD

: 2015

: Journal of Neuroinflammation

: JOURNAL OF NEUROINFLAMMATION

: J NEUROINFLAMM

: ARTN 81

: 12

: 6

: 1742-2094

DOI: https://doi.org/10.1186/s12974-015-0305-9

Conclusions: JZL184 decreased the proinflammatory reactions of microglia and reduced the total A beta burden and its precursors in the APdE9 mouse model. It also reduced the proinflammatory responses of microglia and astrocytes isolated from adult mice.

s12974-015-0305-9.pdf