A1 Refereed original research article in a scientific journal

Monoacylglycerol lipase inhibitor JZL184 reduces neuroinflammatory response in APdE9 mice and in adult mouse glial cells




AuthorsPihlaja R, Takkinen J, Eskola O, Vasara J, Lopez-Picon FR, Haaparanta-Solin M, Rinne JO

PublisherBIOMED CENTRAL LTD

Publication year2015

JournalJournal of Neuroinflammation

Journal name in sourceJOURNAL OF NEUROINFLAMMATION

Journal acronymJ NEUROINFLAMM

Article numberARTN 81

Volume12

Number of pages6

ISSN1742-2094

eISSN1742-2094

DOIhttps://doi.org/10.1186/s12974-015-0305-9


Abstract

Conclusions: JZL184 decreased the proinflammatory reactions of microglia and reduced the total A beta burden and its precursors in the APdE9 mouse model. It also reduced the proinflammatory responses of microglia and astrocytes isolated from adult mice.



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Last updated on 2024-26-11 at 19:41