A1 Refereed original research article in a scientific journal

Monoacylglycerol lipase inhibitor JZL184 reduces neuroinflammatory response in APdE9 mice and in adult mouse glial cells



Authors: Pihlaja R, Takkinen J, Eskola O, Vasara J, Lopez-Picon FR, Haaparanta-Solin M, Rinne JO

Publisher: BIOMED CENTRAL LTD

Publication year: 2015

Journal: Journal of Neuroinflammation

Journal name in source: JOURNAL OF NEUROINFLAMMATION

Journal acronym: J NEUROINFLAMM

Article number: ARTN 81

Volume: 12

Number of pages: 6

ISSN: 1742-2094

eISSN: 1742-2094

DOI: https://doi.org/10.1186/s12974-015-0305-9


Abstract

Conclusions: JZL184 decreased the proinflammatory reactions of microglia and reduced the total A beta burden and its precursors in the APdE9 mouse model. It also reduced the proinflammatory responses of microglia and astrocytes isolated from adult mice.



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Last updated on 2024-26-11 at 19:41