A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä

Monoacylglycerol lipase inhibitor JZL184 reduces neuroinflammatory response in APdE9 mice and in adult mouse glial cells




TekijätPihlaja R, Takkinen J, Eskola O, Vasara J, Lopez-Picon FR, Haaparanta-Solin M, Rinne JO

KustantajaBIOMED CENTRAL LTD

Julkaisuvuosi2015

JournalJournal of Neuroinflammation

Tietokannassa oleva lehden nimiJOURNAL OF NEUROINFLAMMATION

Lehden akronyymiJ NEUROINFLAMM

Artikkelin numeroARTN 81

Vuosikerta12

Sivujen määrä6

ISSN1742-2094

eISSN1742-2094

DOIhttps://doi.org/10.1186/s12974-015-0305-9


Tiivistelmä

Conclusions: JZL184 decreased the proinflammatory reactions of microglia and reduced the total A beta burden and its precursors in the APdE9 mouse model. It also reduced the proinflammatory responses of microglia and astrocytes isolated from adult mice.



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